Oxidation-Specific Biomarkers and Risk of Peripheral Artery Disease

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:61

Article

Bertoia, Monica L.^1,2  Pai, Jennifer K.^3,4  Lee, Jun-Hee^5,6  Taleb, Adam⁵  Joosten, Michel M.^1,2,7,8  Mittleman, Murray A.^1,3  Yang, Xiaohong⁵  Witztum, Joseph L.⁵  Rimm, Eric B.^2,3,4  Tsimikas, Sotirios⁵  Mukamal, Kenneth J.^1,2 

[1] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[4] Harvard Univ, Brigham & Womens Hosp, Channing Div Network Med, Dept Med,Med Sch, Boston, MA 02115 USA

[5] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[6] Hallym Univ, Div Cardiol, Kang Dong Sacred Heart Hosp, Med Ctr, Seoul, South Korea

[7] Top Inst Food & Nutr, Wageningen, Netherlands

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands

关键词: autoantibodies;    biomarker;    immune complex;    lipoprotein (a);    oxidized phospholipids;    peripheral artery disease;   

DOI  :  10.1016/j.jacc.2013.02.047

来源: Elsevier

【 摘 要 】

Objectives The goal of this study was to examine the prospective association between oxidation-specific biomarkers, primarily oxidized phospholipids (OxPL) on apolipoprotein B-100-containing lipoproteins (OxPL/apoB) and lipoprotein (a) [Lp(a)], and risk of peripheral artery disease (PAD). We examined, as secondary analyses, indirect measures of oxidized lipoproteins, including autoantibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and apolipoprotein B-100 immune complexes (ApoB-IC). Background Biomarkers to predict the development of PAD are lacking. OxPL circulate in plasma, are transported by Lp(a), and deposit in the vascular wall and induce local inflammation. Methods The study population included 2 parallel nested case-control studies of 143 men within the Health Professionals Follow-up Study (1994 to 2008) and 144 women within the Nurses' Health Study (1990 to 2010) with incident confirmed cases of clinically significant PAD, matched 1: 3 to control subjects. Results Levels of OxPL/apoB were positively associated with risk of PAD in men and women: pooled relative risk: 1.37, 95% confidence interval: 1.19 to 1.58 for each 1-SD increase after adjusting age, smoking, fasting status, month of blood draw, lipids, body mass index, and other cardiovascular disease risk factors. Lp(a) was similarly associated with risk of PAD (pooled adjusted relative risk: 1.36; 95% confidence interval: 1.18 to 1.57 for each 1-SD increase). Autoantibodies to MDA-LDL and ApoB-IC were not consistently associated with risk of PAD. Conclusions OxPL/apoB were positively associated with risk of PAD in men and women. The major lipoprotein carrier of OxPL, Lp(a), was also associated with risk of PAD, reinforcing the key role of OxPL in the pathophysiology of atherosclerosis mediated by Lp(a). (C) 2013 by the American College of Cardiology Foundation

【 授权许可】

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