Thoracic Aortic Aneurysm and Dissection

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:64

Review

Goldfinger, Judith Z.^1,2  Halperin, Jonathan L.^1,2  Marin, Michael L.³  Stewart, Allan S.⁴  Eagle, Kim A.⁵  Fuster, Valentin^1,2 

[1] Zena & Michael A Wiener Cardiovasc Inst, Div Cardiol, Dept Med, New York, NY USA

[2] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Div Vasc Surg, Dept Surg, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Cardiothorac Surg, New York, NY 10029 USA

[5] Univ Michigan, Hlth Syst & Med Sch, Samuel & Jean A Frankel Cardiovasc Ctr, Dept Med, Ann Arbor, MI USA

关键词: aortic aneurysm;    cardiac surgical procedures;    endovascular procedures;    Marfan syndrome;    risk factors;    transforming growth factor beta;   

DOI  :  10.1016/j.jacc.2014.08.025

来源: Elsevier

【 摘 要 】

Aortic dissection is the most devastating complication of thoracic aortic disease. In the more than 250 years since thoracic aortic dissection was first described, much has been learned about diseases of the thoracic aorta. In this review, we describe normal thoracic aortic size; risk factors for dissection, including genetic and inflammatory conditions; the underpinnings of genetic diseases associated with aneurysm and dissection, including Marfan syndrome and the role of transforming growth factor beta signaling; data on the role for medical therapies in aneurysmal disease, including beta-blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors; prophylactic surgery for aneurysm; surgical techniques for the aortic root; and surgical and endovascular management of aneurysm and dissection for different aortic segments. (C) 2014 by the American College of Cardiology Foundation.

【 授权许可】

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