Training for a First-Time Marathon Reverses Age-Related Aortic Stiffening

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:75

Article

Bhuva, Anish N.^1,2  D'Silva, Andrew³  Torlasco, Camilla^2,4  Jones, Siana¹  Nadarajan, Niromila¹  Van Zalen, Jet²  Chaturvedi, Nish¹  Lloyd, Guy²  Sharma, Sanjay³  Moon, James C.^1,2  Hughes, Alun D.¹  Manisty, Charlotte H.^1,2 

[1] UCL, Inst Cardiovasc Sci, London, England

[2] Barts Hlth NHS Trust, Dept Cardiovasc Imaging, Barts Heart Ctr, London, England

[3] St Georges Univ London, Cardiol Clin & Acad Grp, London, England

[4] San Luca Hosp, Dept Cardiovasc Neural & Metab Sci, IRCCS, Ist Auxol Italiano, Lucca, Italy

关键词: aging;    aortic stiffness;    blood pressure;    cardiovascular magnetic resonance;    exercise training;    marathon;   

DOI  :  10.1016/j.jacc.2019.10.045

来源: Elsevier

【 摘 要 】

BACKGROUND Aging increases aortic stiffness, contributing to cardiovascular risk even in healthy individuals. Aortic stiffness is reduced through supervised training programs, but these are not easily generalizable. OBJECTIVES The purpose of this study was to determine whether real-world exercise training for a first-time marathon can reverse age-related aortic stiffening. METHODS Untrained healthy individuals underwent 6 months of training for the London Marathon. Assessment pre-training and 2 weeks post-marathon included central (aortic) blood pressure and aortic stiffness using cardiovascular magnetic resonance distensibility. Biological aortic age was calculated from the baseline chronological age-stiffness relationship. Change in stiffness was assessed at the ascending (Ao-A) and descending aorta at the pulmonary artery bifurcation (Ao-P) and diaphragm (Ao-D). Data are mean changes (95% confidence intervals [Cis]). RESULTS A total of 138 first-time marathon completers (age 21 to 69 years, 49% mate) were assessed, with an estimated training schedule of 6 to 13 mites/week. At baseline, a decade of chronological aging correlated with a decrease in Ao-A, Ao-P, and Ao-D distensibility by 2.3, 1.9, and 3.1 x 10(-3) mm Hg-1, respectively (p < 0.05 for all). Training decreased systolic and diastolic central (aortic) blood pressure by 4 mm Hg (95% CI: 2.8 to 5.5 mm Hg) and 3 mm Hg (95% CI: 1.6 to 3.5 mm Hg). Descending aortic distensibility increased (Ao-P: 9%; p 0.009; Ao-D: 16%; p = 0.002), white remaining unchanged in the Ao-A. These translated to a reduction in aortic age by 3.9 years (95% 0: 11 to 7.6 years) and 4.0 years (95% 0: 1.7 to 8.0 years) (Ao-P and Ao-D, respectively). Benefit was greater in older, mate participants with slower running times (p < 0.05 for all). CONCLUSIONS Training for and completing a marathon even at relatively low exercise intensity reduces central blood pressure and aortic stiffness-equivalent to a similar to 4-year reduction in vascular age. Greater rejuvenation was observed in older, slower individuals. (C) 2020 by the American College of Cardiology Foundation.

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