Asymmetric total synthesis of (-)-perforanoid A

TETRAHEDRON

卷:73

Article

Lv, Chao²  Tu, Qian¹  Gong, Jianxian¹  Hao, Xiaojiang²  Yang, Zhen¹ 

[1] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen 518055, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

关键词: (-)-Perforanoid A;    Lemonoids;    Asymmetric total synthesig;    Rhodium catalyzed;    Intramolecular Pauson-Khand;   

DOI  :  10.1016/j.tet.2017.03.072

来源: Elsevier

【 摘 要 】

Asymmetric total synthesis of ( - )-perforanoid A, a novel limonoid isolated from the leaves of Harrisonia perforate, has been achieved. The key features of our total synthesis include the Rh-catalyzed intramolecular Pauson Khand reaction of an allene and an alkene, the Pd-catalyzed lactonization of an allylic alcohol with a vinyl ether, and the enantioselective alkenylation of 3-furaldehyde. (C) 2017 Published by Elsevier Ltd.

【 授权许可】

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