Not quite the last word on the Perkin reaction

TETRAHEDRON

卷:70

Article

Edwards, Mark¹  Rourk, Paul M.⁴  Riby, Philip G.²  Mendham, Andrew P.³ 

[1] Univ Greenwich, Sch Sci, Chatham ME4 4TB, Kent, England

[2] Liverpool John Moores Univ, Liverpool L3 3AF, Merseyside, England

[3] Univ Greenwich, Fac Sci & Engn, Chatham ME4 4TB, Kent, England

[4] Univ Greenwich, Sch Chem & Life Sci, London SE18 6PF, England

关键词: Perkin reaction;    Microwave;    Water;    PFA vessels;    Mechanism proposal;   

DOI  :  10.1016/j.tet.2014.07.053

来源: Elsevier

【 摘 要 】

Microwave irradiation does not accelerate the rate of the Perkin reaction carried out under normal atmospheric pressure. Water is an essential yet catalytic reactant for the Perkin reaction to occur. Containment of the Perkin reaction in a sealed vessel improves the yield. Two pressure increases are observed during a 4 h reaction time. An induction period is seen in the Perkin reaction when sodium acetate is used as a base. A re-appraisal of the reaction mechanism is proposed on the basis of these observations. The use of PFA (R) reaction vessels enables the Perkin reaction to occur under aqueous conditions for around 80 reactions/vessel. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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