A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

TETRAHEDRON

卷:71

Article

Salomon, Pierre¹  Kosnik, Wioletta¹  Zard, Samir Z.¹ 

[1] Ecole Polytech, CNRS, Dept Chim, Lab Synt Organ Associe, F-91128 Palaiseau, France

关键词: Radical addition;    Xanthates;    Fluorine;   

DOI  :  10.1016/j.tet.2014.11.021

来源: Elsevier

【 摘 要 】

An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free