Leccinine A, an endoplasmic reticulum stress-suppressive compound from the edible mushroom Leccinum extremiorientale

TETRAHEDRON

卷:67

Article

Choi, Jae-Hoon¹  Ozawa, Nobuhiko¹  Yamakawa, Yasuhiro¹  Nagai, Kaoru²  Hirai, Hirofumi¹  Kawagishi, Hirokazu^1,3 

[1] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Suruga Ku, Shizuoka 4228529, Japan

[2] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Epigenet Med, Yamanashi 4093898, Japan

[3] Shizuoka Univ, Grad Sch Sci & Technol, Suruga Ku, Shizuoka 4228529, Japan

关键词: Endoplasmic reticulum stress suppression;    Mushroom;    Leccinum extremiorientale;    Structural determination;   

DOI  :  10.1016/j.tet.2011.05.052

来源: Elsevier

【 摘 要 】

Leccinine A (1) along with a known compound (2), were isolated from the edible mushroom Leccinum extremiorientale. The structure of 1 was determined by the interpretation of spectral data. Leccinine A showed protective activity against endoplasmic reticulum stress-dependent cell death. Seven analogues (3-9) of 1 were synthesized in order to evaluate the structure-activity relationship, and the result indicated that the formamide group of 1 was indispensable for the activity. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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