H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles

TETRAHEDRON

卷:73

Article

Ghohe, Narges Mandizadeh¹  Tayebee, Reza¹  Amini, Mostafa M.²  Osatiashtiani, Amin³  Isaacs, Mark A.³  Lee, Adam F.^3,4 

[1] Hakim Sabzevari Univ, Sch Sci, Dept Chem, Sabzevar 9617976487, Iran

[2] Shahid Beheshti Univ, Dept Chem, GC, Tehran 1983963113, Iran

[3] Aston Univ, European Bioenergy Res Inst, Birmingham B4 7ET, W Midlands, England

[4] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

关键词: Vanadia;    SBA-15;    Heteropolyacid;    3-Substituted indoles;    Solventless;   

DOI  :  10.1016/j.tet.2017.08.030

来源: Elsevier

【 摘 要 】

Functionalization of mesoporous SBA-15 frameworks by transition metal oxides offers a flexible route to fabricate new heterogeneous catalysts. Here, an inorganic-organic hybrid nanoporous catalyst H5PW10V2O40@VOx/SBA-15-NH2, was prepared and utilized as an efficient, eco-friendly, and recyclable catalyst for the one-pot, multi-component synthesis of 3-substituted indoles by indole substitution with aldehydes and malononitrile under solvent-free conditions. Catalysts were prepared by the non-covalent attachment of H5PW10V2O40 to a 3 wt%VOx/SBA-15 nanoporous support through a 3-(triethoxysilyl) propylamine linker. VOxiSBA-15 was prepared by a one-pot hydrothermal synthesis from TEOS and vanadium(V) oxytri-tert-butoxide [VO(O-Bu-t)(3)]. The resulting H5PW10V2O40@VOx/SBA-15-NH2 material was characterized by bulk and surface analysis including N-2 porosimetry, FE-SEM, XRD, XPS, TGADTA, UV Vis and ICP-OES, evidencing retention of the heteropolyacid Keggin structure. H5PW10V2O40@VOx/SBA-15-NH2 exhibits high activity and excellent yields (70-95%) of 3-substituted indoles under mild conditions, with negligible deactivation. (C) 2017 Elsevier Ltd. All rights reserved.

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