Exploiting C-H borylation for the multidirectional elaboration of 2-halopyridines

TETRAHEDRON

卷:76

Article

Reuven, Jonathan A.¹  Salih, Omar A.^1,2  Sadler, Scott A.¹  Thomas, Carys L.¹  Steel, Patrick G.¹ 

[1] Univ Durham, Dept Chem, Sci Labs, South Rd, Durham DH1 3LE, England

[2] Univ Mosul, Coll Educ Pure Sci, Dept Chem, Mosul, Iraq

关键词: Pyridine;    C-H borylation;    Suzuki-Miyaura;    Multidirectional synthesis;   

DOI  :  10.1016/j.tet.2019.130836

来源: Elsevier

【 摘 要 】

Regioselectively polysubstituted pyridines can be efficiently accessed from 2-halopyridines via a sequence involving C-H borylation, Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution chemistry. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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