Dimerization of functional pyrroloindolizines for the synthesis of complex myrmicarin alkaloids

TETRAHEDRON

卷:66

Article

Ondrus, Alison E.¹  Kaniskan, H. Uemit¹  Movassaghi, Mohammad¹ 

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

关键词: Alkaloid;    Synthesis;    Acylation;    Pyrrole;    Cyclization;    Myrmicarin;    Claisen condensation;   

DOI  :  10.1016/j.tet.2010.04.006

来源: Elsevier

【 摘 要 】

The union of functionalized pyrroloindolizines for the synthesis of heterodimeric products relevant to myrmicarin alkaloids is described. Design and synthesis of tricyclic substrates and new methods for their union enable the investigation of late-stage cyclopentannulation strategies. The rapid assembly of dimeric structures using unique modes of pyrroloindolizine reactivity presents a concise approach to the dimeric myrmicarins and relevant derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

Free