Amide-directed arylation of sp3 C-H bonds using Pd(II) and Pd(0) catalysts

TETRAHEDRON

卷:66

Article

Wasa, Masayuki¹  Yu, Jin-Quan¹ 

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

关键词: Amide;    Palladium;    Arylation;    sp(3) C-H activation;   

DOI  :  10.1016/j.tet.2010.03.111

来源: Elsevier

【 摘 要 】

Protocols to effect beta-arylation of sp(3) C-H bonds via Pd(II)/(IV) and Pd(0)/(II) catalytic cycles have been achieved using a newly developed monodentate CONHC6F5 directing group. These reactions provide an unprecedented means to functionalize sp(3) C-H bonds in aliphatic carboxylic acid-derived substrates. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

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