Carbohydrate-derived iminium salt organocatalysts for the asymmetric epoxidation of alkenes

TETRAHEDRON

卷:70

Article

Page, Philip C. Bulman¹  Chan, Yohan¹  Liddle, John³  Elsegood, Mark R. J.² 

[1] Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England

[2] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[3] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

关键词: Epoxidation;    Organocatalysis;    Asymmetric epoxidation;    Carbohydrate;    Iminium salt;   

DOI  :  10.1016/j.tet.2014.07.052

来源: Elsevier

【 摘 要 】

A new family of carbohydrate-based dihydroisoquinolinium salts has been prepared and tested for potential as asymmetric catalysts for the epoxidation of unfunctionalized alkene substrates, providing up to 57% ee in the product epoxides. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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