Prolinal dithioacetals: Highly efficient organocatalysts for the direct nitro-Michael additions in both organic and aqueous media

TETRAHEDRON

卷:73

Article

Mandal, Tanmay¹  Kuo, Wen¹  Su, Matthew¹  Bhowmick, Kartick¹  Zhao, John C. -G.¹ 

[1] Univ Texas San Antonio, Dept Chem, One UTSA Circle, San Antonio, TX 78249 USA

关键词: Proline;    Organocatalysis;    Nitro-Michael;    Thioacetal;    Water;    Brine;   

DOI  :  10.1016/j.tet.2017.10.008

来源: Elsevier

【 摘 要 】

Some novel prolinal dithioacetal derivatives have been synthesized and applied as the organocatalysts for the direct Michael addition of ketones and aldehydes to nitroalkenes. High enantioselectivities and diastereoselectivities have been obtained in both organic and aqueous media (dichloromethane, water, or brine). (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free