Copper-catalyzed cycloisomerization of alkynylaziridines to access functionalized 2-substituted-4-formylpyrroles

TETRAHEDRON

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Article

Westermeyer, Anne^1,2  Guillamot, Gerard²  Phansavath, Phannarath¹  Ratovelomanana-Vidal, Virginie¹ 

[1] PSL Univ, Inst Chem Life & Hlth Sci, CSB2D Team, Chim ParisTech,CNRS, 11 Rue Pierre & Marie Curie, F-75005 Paris, France

[2] SEQENS, 2-8 Rue Rouen, F-78440 Porcheville, France

关键词: Pyrroles;    Copper-catalysis;    Alkynylaziridines;    Cycloisomerization;   

DOI  :  10.1016/j.tet.2020.131221

来源: Elsevier

【 摘 要 】

The copper-catalyzed cycloisomerization of alkynylaziridines has been developed to access 2-substituted-4-formylpyrroles. The reaction proved to be tolerant to aryl and alkyl-substituted substrates which were readily prepared from the corresponding enynes. This atom-economical catalytic process gives a convenient and regioselective access to a wide range of diversely 2-substituted-4-formylpyrroles in a two-step procedure. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

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