Superelectrophilic nazarov cyclizations with N-heterocycles

TETRAHEDRON

卷:76

Article

Vuong, Hien¹  Amadou, Harouna¹  Stentzel, Michael R.¹  Klumpp, Douglas A.¹ 

[1] Northern Illinois Univ, Dept Chem & Biochem, De Kalb, IL 60115 USA

关键词: Heterocycles;    Nazarov;    Indanone;    Superacid;    Superelectrophile;   

DOI  :  10.1016/j.tet.2020.131644

来源: Elsevier

【 摘 要 】

A series of Nazarov cyclizations has been studied involving N-heterocyclic-substituted 1-arylprop-2-en-1-one derivatives (aza-chalcones). Superacid catalyzed reactions of these derivatives provide good yields of heterocyclic-substituted 1-indanones. A mechanism is proposed involving diprotonated, super-electrophilic intermediates. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

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