Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering

TETRAHEDRON

卷:82

Article

Marshall, James R.¹  Mangas-Sanchez, Juan^1,2,3  Turner, Nicholas J.¹ 

[1] Univ Manchester, Manchester Inst Biotechnol, Dept Chem, 131 Princess St, Manchester M1 7DN, Lancs, England

[2] CSIC, Inst Chem Synth & Homogeneous Catalysis, Pedro Cerbuna 12, Zaragoza 50009, Spain

[3] ARAID Fdn, Zaragoza, Spain

关键词: Biocatalysis;    Protein engineering;    Enzyme discovery;    Amides;    Halogenases;    Carbene and nitrene transfers;   

DOI  :  10.1016/j.tet.2021.131926

来源: Elsevier

【 摘 要 】

Despite the growing impact of enzyme catalysis in industrial chemistry, the full potential of this technology is yet to be unlocked. Accessing new chemistries and expanding the scope of existing reactions is necessary in order to make biocatalysis a pivotal technology in the manufacturing of chemicals across the whole industrial spectrum. This review highlights how the biocatalytic toolbox for synthetic chemistry has recently been expanded by extending the scope of industrially relevant reactions, and the addition of new reactions via enzyme discovery or protein engineering. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free