Oligopyridones: preparation and their folding behavior in polar aprotic solvents

TETRAHEDRON

卷:65

Article

Liang, Chih-Kai¹  Wang, Po-Shih¹  Leung, Man-kit^1,2 

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Inst Polymer Sci & Engn, Taipei 106, Taiwan

关键词: Helical structure;    Copper reagents;    C-N coupling;   

DOI  :  10.1016/j.tet.2008.12.024

来源: Elsevier

【 摘 要 】

The oligomerization of 5-bromo-2-hydroxypyridine through a CuI catalyzed one-pot condensation tactics was developed. A series of oligopyridones, from dipyridione to penta-pyridone, were therefore synthesized via the CuI-promoted C-N coupling reactions. The oligopyridones favor to have folded conformations in polar aprotic solvents. These were confirmed by using (1)H NMR, NOESY, and 1D-NOE experiments. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

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