Short syntheses of the indole alkaloids alocasin A, scalaridine A, and hyrtinadine A-B

TETRAHEDRON

卷:72

Article

Ansari, Nurul H.¹  Soderberg, Bjorn C. G.¹ 

[1] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

关键词: N-heterocyclization;    Palladium-catalyzed;    Indole;    Alkaloid synthesis;   

DOI  :  10.1016/j.tet.2016.05.057

来源: Elsevier

【 摘 要 】

Expedient syntheses of the indole alkaloids alocasin A, scalaridine A, and hyrtinadine A-B are presented. All four natural products contain one or two 5-hydroxyindolyl units. Three palladium catalyzed reactions, an alkyne hydrostannylation, a Kosugi-Migita-Stille cross coupling and a reductive N-heterocyclization are the key steps in the syntheses. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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