Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade

TETRAHEDRON

卷:76

Article

Clarke, Aimee K.¹  Rossi-Ashton, James A.¹  Taylor, Richard J. K.¹  Unsworth, William P.¹ 

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

关键词: Akuammiline alkaloids;    Ynones;    Dearomatisation;    Indole;    Cascade reactions;   

DOI  :  10.1016/j.tet.2020.131392

来源: Elsevier

【 摘 要 】

Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynonetethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives. (C) 2020 Elsevier Ltd. All rights reserved.

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