Radical N-heterocyclic carbene catalysis for β-ketocarbonyl synthesis

TETRAHEDRON

卷:91

Article

Ishii, Takuya¹  Nagao, Kazunori¹  Ohmiya, Hirohisa^1,2 

[1] Kanazawa Univ, Grad Sch Med Sci, Div Pharmaceut Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan

[2] JST, PRESTO, Saitama 3320012, Japan

关键词: N-Heterocyclic carbene;    Radical;    Aldehyde;    beta-Ketocarbonyls;   

DOI  :  10.1016/j.tet.2021.132212

来源: Elsevier

【 摘 要 】

N-Heterocyclic carbene-catalyzed radical cross-coupling between aldehydes and alpha-bromoesters or alpha-bromoamides is described. beta-Ketocarbonyl compounds having a quaternary carbon center at the alpha-position can be synthesized under mild reaction conditions. Both aromatic and aliphatic aldehydes are suitable acyl donors by employing proper NHC catalyst precursors. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

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