A mild, copper-catalysed amide deprotection strategy: use of tert-butyl as a protecting group

TETRAHEDRON

卷:70

Article

Evans, Vikki¹  Mahon, Mary F.¹  Webster, Ruth L.¹ 

[1] Univ Bath, Bath BA2 7AY, Avon, England

关键词: Amides;    Deprotection;    Catalysis;    Copper;   

DOI  :  10.1016/j.tet.2014.07.080

来源: Elsevier

【 摘 要 】

Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)(2) is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

【 授权许可】

Free