Stereoselective total synthesis of cochliomycin A

TETRAHEDRON

卷:70

Article

Wang, Linlin¹  Gao, Yangguang²  Liu, Jun¹  Cai, Chao¹  Du, Yuguo^1,2 

[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

[2] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China

关键词: Cochliomycin A;    Total synthesis;    Resorcylic acid lactones;   

DOI  :  10.1016/j.tet.2014.03.001

来源: Elsevier

【 摘 要 】

A convergent and stereoselective synthesis of cochliomycin A, a 14-membered resorcyclic acid lactone, based on chiron approach is described. The key reactions involved olefin cross-metathesis and sodium hydride promoted one-pot intramolecular lactonization. L-Arabinose was used as a chiral pool material for the construction of the key fragment. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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