A novel strategy for the synthesis of 6H-chromeno [4, 3-b] quinoline by intramolecular Heck cyclization

TETRAHEDRON

卷:73

Article

Shiri, Morteza¹  Fathollahi-Lahroud, Mina¹  Yasaei, Zahra¹ 

[1] Alzahra Univ, Fac Phys & Chem, Dept Chem, Tehran 1993893973, Iran

关键词: Intramolecular Heck reaction;    6H-chromeno [4,3-b] quinolines;    Palladium;    Indole;   

DOI  :  10.1016/j.tet.2017.03.043

来源: Elsevier

【 摘 要 】

A novel procedure for the synthesis of various derivatives of 6H-chromeno [4, 3-b] quinolines from intramolecular Heck reaction of 2-chloro-3-(phenoxymethyl) quinolines is described in this study. Intramolecular cyclization of N-alkylated indoles was efficiently investigated as well. The reaction is catalyzed by bis (triphenylphosphine) palladium (II) dichloride in acetonitrile at 80 degrees C. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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