Enantioselective reactions catalyzed by phosphine oxides

TETRAHEDRON

卷:75

Review

Ayad, Tahar¹  Gernet, Aurelie²  Pirat, Jean-Luc²  Virieux, David² 

[1] PSL Univ, Inst Chem Life & Hlth Sci, CSB2D Team, Chim ParisTech,CNRS, 11 Rue Pierre & Marie Curie, F-75005 Paris, France

[2] Univ Montpellier, CNRS, ENSCM, ICGM, Montpellier, France

关键词: Enantioselective catalysis;    Lewis bases;    Phosphine oxides;    Hypervalent silicon intermediates;   

DOI  :  10.1016/j.tet.2019.06.042

来源: Elsevier

【 摘 要 】

The development of chiral small organic molecules that serve as Lewis base catalysts promoting highly stereoselective transformations has been the subject of intense research over the past decades. As a matter of fact, among the plethora of molecules used as Lewis bases, chiral phosphine oxides have thoroughly been overlooked by the organic synthetic community. Thus, this review focuses exclusively on Lewis base catalysis mediated by chiral phosphine oxides with emphasis on mechanistic aspects, covering most of the publications related to this field since their first use as organocatalyst in 2005 until the end of March 2019. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free