Buffer-induced, selective mono-C-alkylation of phloroglucinol:: application to the synthesis of an advanced intermediate of catechin

TETRAHEDRON

卷:60

Article

Gissot, A ; Wagner, A ; Mioskowski, C

关键词: flavonoids;    polyphenol compounds;    phloroglucinol;    alkylation;    synthetic methodology;   

DOI  :  10.1016/j.tet.2004.06.026

来源: Elsevier

【 摘 要 】

A straightforward mono-selective and C-specific alkylation of phloroglucinol with activated alkyl halides is presented. The use of water as solvent limits the amount of over-alkylated by-products. Provided some minor changes in the experimental conditions, hydrophobic cinnamyl halides can also be reacted, thus giving a direct access to advanced intermediates of natural flavonoids. (C) 2004 Elsevier Ltd. All rights reserved.

【 授权许可】

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