TETRAHEDRON | 卷:72 |
Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles | |
Article | |
Cano, Rafael1,2  Perez, Juana M.3,4  Ramon, Diego J.3,4  McGlacken, Gerard P.1,2  | |
[1] Univ Coll Cork, Dept Chem, Cork, Ireland | |
[2] Univ Coll Cork, Analyt & Biol Chem Res Facil ABCRF, Cork, Ireland | |
[3] Univ Alicante, Inst Sintesis Organ ISO, Apdo 99, E-03080 Alicante, Spain | |
[4] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain | |
关键词: Direct arylation; Heterogeneous catalysis; Heterocycles; Magnetite; Palladium; | |
DOI : 10.1016/j.tet.2015.12.039 | |
来源: Elsevier | |
【 摘 要 】
Palladium impregnated on magnetite is an efficient, cheap and easy to prepare catalyst for the direct arylation of heterocycles. Good yields are afforded under relatively mild conditions and a broad substrate scope is evident. The catalyst is regioselective in many cases, affording arylated products, at the C2- or C3-position (depending of the heterocycle used). The methodology can be extended to prepare chromenes through an intramolecular direct arylation reaction. Some evidence is provided for two catalyst deactivation pathways, which prevents efficient recycling. (C) 2015 Published by Elsevier Ltd.
【 授权许可】
Free
【 预 览 】
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10_1016_j_tet_2015_12_039.pdf | 701KB | download |