Novel approach to the synthesis of aliphatic and aromatic α-keto acids

TETRAHEDRON

卷:68

Article

Balducci, Daniele¹  Conway, Philip A.¹  Sapuppo, Giulia¹  Mueller-Bunz, Helge¹  Paradisi, Francesca¹ 

[1] Univ Coll Dublin, Ctr Synth & Chem Biol, UCD Sch Chem & Chem Biol, Dublin 4, Ireland

关键词: alpha-Keto acids;    Aromatic;    Aliphatic;    Aldol reaction;   

DOI  :  10.1016/j.tet.2012.06.078

来源: Elsevier

【 摘 要 】

A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile and innovative with excellent carbon economy and recycling of the glycine by-product. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free