Comparative studies of palladium and copper-catalysed γ-arylation of silyloxy furans with diaryliodonium salts

TETRAHEDRON

卷:75

Article

Alexander, Taylor S.¹  Clay, Travis J.¹  Maldonado, Bryan¹  Nguyen, Johny M.¹  Martin, David B. C.¹ 

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

关键词: Palladium catalysis;    Copper catalysis;    Arylation;    Butenolides;    Silyloxy furan;    Diaryliodonium salts;   

DOI  :  10.1016/j.tet.2019.02.042

来源: Elsevier

【 摘 要 】

The gamma-arylation of substituted silyl-activated butenolides has been studied using a broad scope of unsymmetrical hypervalent diaryliodonium salts via a palladium- or copper-catalysed coupling reaction, yielding interesting reactivity trends. The mild catalytic conditions and coupling partner variability provide access to synthetically useful building blocks toward the pursuit of aryl-lactone containing natural products and allows for facile diversification. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free