Double Michael addition/aza-cyclization: a valuable sequence for the construction of symmetrical and unsymmetrical spirobarbiturate-pyridines

TETRAHEDRON

卷:71

Article

De Crescentini, Lucia¹  Attanasi, Orazio A.¹  Campisi, Linda A.¹  Favi, Gianfranco¹  Lillini, Samuele²  Ursini, Fabrizio³  Mantellini, Fabio¹ 

[1] Univ Urbino Carlo Bo, Sect Organ Chem & Organ Nat Cpds, Dept Biomol Sci, I-61029 Urbino, PU, Italy

[2] Dompe Farmaceutici Spa, I-80131 Naples, Italy

[3] Dompe Farmaceutici Spa, I-67100 Laquila, Italy

关键词: Spiro compounds;    Michael addition;    Pyridines;    Barbituric acids;    1,2-Diaza-1,3-dienes;   

DOI  :  10.1016/j.tet.2015.04.004

来源: Elsevier

【 摘 要 】

A simple one-pot procedure for the preparation of symmetrical bis-hydrazone functionalized barbiturates, and a step-by step sequence for the synthesis of analogous unsymmetrical derivatives were developed. Their treatment in acid conditions furnish the symmetrical- and unsymmetrical-spirobarbiturate-pyridines, respectively. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

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