Total synthesis of (-)-petrosiol E

TETRAHEDRON

卷:70

Article

Wang, Linlin^1,2  Zhang, Xing^1,2  Liu, Jun¹  Du, Yuguo^1,2 

[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

[2] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China

关键词: Petrosiol E;    Total synthesis;    Petrosiols;    Natural products;   

DOI  :  10.1016/j.tet.2014.09.030

来源: Elsevier

【 摘 要 】

(-)-Petrosiol E, a metabolite of sponge Petrosia strongylata, has been synthesized in 32% overall yield from cheap natural D-xylose in 10 steps. Our strategy provides an efficient way for the total synthesis of other petrosiol members, featuring the three contiguous stereogenic centers are easily constructed from D-xylose chiral template. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free