Transition-metal-free direct trifluoromethylthiolation of electron-rich aromatics using CF3SO2Na in the presence of PhPCl2

TETRAHEDRON

卷:73

Article

Zhao, Xia¹  Zheng, Xiancai¹  Tian, Miaomiao¹  Sheng, Jianqiao¹  Tong, Yifan¹  Lu, Kui² 

[1] Tianjin Normal Univ, Minist Educ, Key Lab Inorgan Organ Hybrid Funct Mat Chem, Tianjin Key Lab Struct & Performance Funct Mol,Co, Tianjin 300387, Peoples R China

[2] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China

关键词: Trifluoromethylthiolation;    CF3SO2Na;    PhPCl2;    Indole;    Electron-rich aromatics;   

DOI  :  10.1016/j.tet.2017.11.019

来源: Elsevier

【 摘 要 】

A novel transition metal-free route for the direct trifluoromethylthiolation of electron-rich aromatics using CF3SO2Na in the presence of PhPCl2 was developed. More specifically, PhPCl2 was used as both a reducing and a chlorinating reagent for the first time in this CF3SO2Na-based trifluoromethylthiolation reaction. The absence of transition metals and the use of cheap and readily available reagents render this method an alternative and practical strategy for the trifluoromethylthiolation of electron-rich aromatics. (C) 2017 Published by Elsevier Ltd.

【 授权许可】

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