Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base

TETRAHEDRON

卷:74

Article

Sbei, Najwa³  Batanero, Belen^1,2  Barba, Fructuoso¹  Haouas, Beya³  Benkhoud, Mohamed Lamine³  Barba, Isidoro¹ 

[1] Univ Alcala, Dept Organ Chem, Madrid 28871, Spain

[2] Univ Alcala, Inst Invest Quim Andres M del Rio IQAR, Madrid 28871, Spain

[3] Univ Tunis El Manor, Fac Sci, Lab Chim Analyt & Electrochim, Tunis 2092, Tunisia

关键词: Quinazolin-2-ones;    N-heterocyclic olefins;    Magnesium sacrificial anode;    Electrogenerated cyanomethyl anion;    Organic isocyanates;   

DOI  :  10.1016/j.tet.2018.03.010

来源: Elsevier

【 摘 要 】

A new series of 3,4-disubstituted quinazolin-2-ones, with potential T-type calcium channel antagonist activity, and new 4-methylene-quinazolin-2-ones, promising catalysts as N-heterocyclic olefins, have been prepared in good yield by a simple reaction between 2-aminobenzophenone, or 2-aminoacetophenone, and cyanomethyl anion electrogenerated by acetonitrile reduction at a graphite electrode, followed by the addition of different organic isocyanates and subsequent heterocyclization. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

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