An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device

TETRAHEDRON

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Article

O'Brien, Matthew¹  Hall, April¹  Schrauwen, John^1,2  van der Made, Joyce^1,2 

[1] Keele Univ, Sch Chem & Phys Sci, Lennard Jones Labs, Borough Newcastle Under ST5 5BG, Staffs, England

[2] Avans Univ Appl Sci, Lovensdijkstr 61-63, NL-4818 AJ Breda, North Brabant, Netherlands

关键词: Low-cost-automation;    Open-source;    Python;    OpenCV;    Raspberry-Pi;    Flow-chemistry;    Amide-formation;    Liquid-liquid extraction;   

DOI  :  10.1016/j.tet.2018.02.043

来源: Elsevier

【 摘 要 】

Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free