Cerium ammonium nitrate: a new catalyst for regioselective protection of glycols

TETRAHEDRON

卷:60

Article

Comin, MJ ; Elhalem, E ; Rodriguez, JB

关键词: glycols;    regioselective monoprotection;    methoxymethyl protecting group;    diisobutyl aluminum hydride;   

DOI  :  10.1016/j.tet.2004.09.097

来源: Elsevier

【 摘 要 】

The regioselective introduction of a methoxymethyl (MOM) group on different type of glycols via an orthoester intermediate was investigated. The novelty presented in this study is the use of ceric ammonium nitrate instead of the previously employed camphorsulfonic acid as catalyst. The monoprotection reaction was revealed to be highly selective when the glycol moiety was in the presence of an ether functionality. (C) 2004 Elsevier Ltd. All rights reserved.

【 授权许可】

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