A folding decalin tetra-urea for transmembrane anion transport

TETRAHEDRON

卷:73

Article

Valkenier, Hennie^1,2  Dias, Christopher M.¹  Butts, Craig P.¹  Davis, Anthony P.¹ 

[1] Univ Bristol, Sch Chem, Cantocks Close, Bristol BS8 1TS, Avon, England

[2] Univ Libre Bruxelles, Ecole Polytech Bruxelles, Engn Mol NanoSyst, Ave FD Roosevelt 50,CP165-64, B-1050 Brussels, Belgium

关键词: Supramolecular chemistry;    Anion binding;    Anion transport;    Host-guest systems;    Urea;    Foldamer;   

DOI  :  10.1016/j.tet.2017.04.064

来源: Elsevier

【 摘 要 】

A new approach to anionophore design combines a trans-decalin scaffold with flexible o-phenylene bisurea side-arms. The scaffold preorganises the side-arms, which can fold to encompass anionic substrates. A prototype has been synthesised by coupling an o-aminophenyl urea to a decalin bis-isocyanate, and has been shown to be active for anion binding and transport. Modelling and NMR studies show that the unbound receptor is capable of intramolecular hydrogen bonding but can reorganise to form up to eight hydrogen bonds to a chloride anion. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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