Iron catalysis for the synthesis of ligands: Exploring the products of hydrophosphination as ligands in cross-coupling

TETRAHEDRON

卷:73

Article

Espinal-Viguri, Maialen¹  Mahon, Mary F.¹  Tyler, Simon N. G.²  Webster, Ruth L.¹ 

[1] Univ Bath, Dept Chem, Claverton Down, Bath BA2 7AY, Avon, England

[2] CatSci Ltd, CBTC2,Capital Business Pk, Cardiff CF3 2PX, S Glam, Wales

关键词: Iron;    Phosphine ligands;    C-C cross-coupling;    Amination;   

DOI  :  10.1016/j.tet.2016.11.058

来源: Elsevier

【 摘 要 】

Catalytic hydrophosphination is a useful technique for the synthesis of phosphines, however, the phosphine products have been little exploited as ligands in catalysis. We have selected three phosphines prepared by iron catalyzed hydrophosphination and used them as ligands in a series of cross-coupling reactions: Heck, Suzuki-Miyaura and Buchwald-Hartwig. Rather than limit the chemistry to simple cross-coupling partners which are almost guaranteed to perform well in these transformations, industrially relevant substrates which are challenging from and electronic and/or steric perspective, along with substrates which contain several heteroatoms, were explored in order to gauge the true potential of these phosphine ligands. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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