Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

TETRAHEDRON

卷:75

Article

Warner, Christopher J. A.¹  Berry, Sian S.¹  Jones, Simon¹ 

[1] Univ Sheffield, Dept Chem, Dainton Bldg,Brook Hill, Sheffield S3 7HF, S Yorkshire, England

关键词: Hydrosilylation;    Asymmetric catalysis;    Phosphine oxide;    Organocatalysis;   

DOI  :  10.1016/j.tet.2019.130733

来源: Elsevier

【 摘 要 】

A series of bifunctional phosphine oxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asymmetric hydrosilylation of ketimines. bis-Phosphine oxides, hydroxyphosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide displayed the highest enantioselectivity of 60%. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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