An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions

TETRAHEDRON

卷:65

Article

Chen, Yu¹  Markina, Nataliya A.¹  Larock, Richard C.¹ 

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

关键词: Microwave-assisted;    One-pot;    Three-component coupling;    Indoles;    Sonogashira coupling;   

DOI  :  10.1016/j.tet.2009.07.075

来源: Elsevier

【 摘 要 】

A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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