A novel method of molecular imprinting applied to the template cholesterol

TALANTA

卷:217

Article

Pesic, Milos P.¹  Todorov, Miljana D.¹  Becskereki, Gergely²  Horvai, George²  Verbic, Tatjana Z.¹  Toth, Blanka² 

[1] Univ Belgrade, Fac Chem, Studentski Trg 12-16, Belgrade 11000, Serbia

[2] Budapest Univ Technol & Econ, Dept Inorgan & Analyt Chem, Szent Gellert Ter 4, H-1111 Budapest, Hungary

关键词: Molecular imprinting;    Steroids;    Cholesterol;    Stigmasterol;    Estradiol;    Cortisol;    Polymers;    Adsorption;   

DOI  :  10.1016/j.talanta.2020.121075

来源: Elsevier

【 摘 要 】

A novel method is successfully tested for non-covalent imprinting. Conditions are used which practically exclude the formation of prepolymerization complexes. The template is cholesterol, and no so-called functional monomer is used. The polymers contain only an acrylic diester crosslinker. The porogen isopropanol prevents even hydrogen bonding between the template and the monomer in the prepolymerization solution. Despite of these apparently very disadvantageous conditions, appreciable imprinting factors for cholesterol and imprinted selectivity against some other steroids are observed, similar to other cholesterol MIPs with proven analytical usefulness.

【 授权许可】

Free