Ion beam analysis (IBA) and instrumental neutron activation analysis (INAA) for forensic characterisation of authentic Viagra® and of sildenafil-based illegal products

TALANTA

卷:224

Article

Romolo, Francesco Saverio¹  Sarilar, Mehmet²  Antoine, Johann³  Mestria, Serena⁴  Rossi, Sabina Strano⁴  Gallidabino, Matteo Davide⁵  Soares de Souza, Guilherme Mauricio⁶  Chytry, Paola⁶  Dias, Johnny Ferraz⁶ 

[1] Univ Bergamo, Dept Law, Via Moroni 255, I-24127 Bergamo, Italy

[2] Univ Technol Delft, Reactor Inst Delft, Delft, Netherlands

[3] Univ West Indies, Int Ctr Environm & Nucl Sci, Nucl Analyt Lab, Mona Campus, Kingston, Jamaica

[4] Univ Cattolica Sacro Cuore, F Policlin Gemelli IRCCS Roma, Forens Toxicol Lab, Dept Hlth Surveillance & Bioeth, Milan, Italy

[5] Northumbria Univ, Fac Hlth & Life Sci, Ctr Forens Sci, Dept Appl Sci, Newcastle Upon Tyne, Tyne & Wear, England

[6] Univ Fed Rio Grande do Sul, Inst Phys, Ion Implantat Lab, Porto Alegre, RS, Brazil

关键词: Illegal pharmaceutical products;    Counterfeit pharmaceutical products;    Dietary supplements;    Neutron activation analysis;    Ion beam analysis;    Forensic analysis;    Sildenafil;    Viagra (R);   

DOI  :  10.1016/j.talanta.2020.121829

来源: Elsevier

【 摘 要 】

Illegal trafficking of pharmaceutical products by criminal organisations is a global threat for public health. Drugs for erectile dysfunction such as phosphodiesterase type 5 inhibitors are the most commonly counterfeited medicines in Europe. The search of possible toxic chemical substances in seized products is needed to provide early warning for public health. Furthermore, the elemental profile of the seized products can be useful in criminal investigations. For the first time an ion beam analysis (IBA) procedure to characterise authentic Viagra (R) tablets and sildenafil-based illegal products is described. Moreover, results are compared with the ones obtained by instrumental neutron activation analysis (INAA) on authentic Viagra (R) tablets in two reactors. IBA results showed that a combination of particle-induced X-ray emission (PIXE) and secondary ion mass spectrometry using primary ions with energies in the range of several MeV (MeV-SIMS) is a powerful tool to characterise different products in a straightforward manner, allowing discrimination between legal and illegal products. INAA allowed accurate elemental quantification and also showed a great potential for the future implementation of an interlaboratory classification system.

【 授权许可】

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