Metal-organic frameworks based fluorescent sensor array for discrimination of flavonoids

TALANTA

卷:203

Article

Liu, Qiao¹  Gao, Jie¹  Zheng, Zhe¹  Ning, Di¹  Wang, Qian¹  Du, Xiao-Meng¹  Zhao, Bo¹  Ruan, Wen-Juan^1,2  Li, Yue^1,2 

[1] Nankai Univ, Coll Chem, 94 Weijin Rd, Tianjin 300071, Peoples R China

[2] Nankai Univ, Minist Educ, Key Lab Adv Energy Mat Chem, Tianjin 300071, Peoples R China

关键词: metal-organic framework;    Sensor array;    Fluorescent response;    Homologous discrimination;    Flavonoids;   

DOI  :  10.1016/j.talanta.2019.05.073

来源: Elsevier

【 摘 要 】

Metal-organic frameworks (MOFs) are hotly investigated as a novel kind of fluorescent sensing materials in recent years. However, the application of MOF sensing to drug analysis is still very difficult yet, because the structural similarity among drug homolog-ues exceeds the discrimination ability of MOFs. Array sensing technique, which relies on the combined responses of a group of sensing materials, is a viable way to solve this problem. In this work, we chose five luminescent MOFs with different fluorophores to construct a fluorescent sensor array for the analysis of flavonoids. With the response pattern of these MOFs and the statistical methods of linear discriminant analysis and hierarchical cluster analysis, nine flavonoids with similar structures were correctly discriminated. By the combination with UV spectrum, our method could even realize the qualification and quantification of the flavonoid samples with unknown concentrations. This work is the first time of using MOFs to successfully distinguish multiple drug homolog-ues.

【 授权许可】

Free