Enantioseparation of binaphthol and its monoderivatives by cyclodextrin-modified capillary zone electrophoresis: A mathematical approach

TALANTA

卷:78

Article

Mofaddel, N.¹  Krajian, H.¹  Villemin, D.²  Desbene, P. L.¹ 

[1] Univ Rouen, LASOC IRCOF & IFRMP, F-27000 Evreux, France

[2] Univ Caen, ENSICAEN, Lab Chim Mol Thioorgan, UMR 6507, F-14050 Caen, France

关键词: Binaphthol derivatives;    Mathematical approach;    Apparent complexation constant;    Enantioseparation;    CD-CZE;   

DOI  :  10.1016/j.talanta.2008.12.027

来源: Elsevier

【 摘 要 】

A simple model for the separation of atropisomers of binaphthol and its monoderivatives by means of cyclodextrin-modified capillary zone electrophoresis (CD-CZE) was used to describe the migration behavior of poly charged enantiomers in a chiral separation system This mathematical a approach allowed for the determination of the optimal cyclodextrin concentrations for the enantioseparation of binaphthols by taking into account the influence of the formed complex mobilities. Moreover. using this theoretical approach, the reversal of the enantiomers' migration order as a function of cyclodextrin concentration was predicated. The apparent complexation constants between the cyclodextrins and the binaphthol and its monoderivatives Could be calculated using a non-linear Curve fitting method and three linear plotting methods (x-reciprocal, y-reciprocal and double reciprocal). Good agreements between the theoretical and experimental cyclodextrin concentrations were obtained. (C) 2008 Elsevier B.V. All rights reserved.

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