Gold nanorod-based localized surface plasmon resonance biosensors: A review

SENSORS AND ACTUATORS B-CHEMICAL

卷:195

Review

Cao, Jie¹  Sun, Tong¹  Grattan, Kenneth T. V.^1,2 

[1] City Univ London, Sch Engn & Math Sci, London EC1V 0HB, England

[2] City Univ London, City Grad Sch, London EC1V 0HB, England

关键词: Localized surface plasmon resonance LSPR;    Gold nanorod;    Biosensors;    Nanoparticles;    Optical fiber sensor;   

DOI  :  10.1016/j.snb.2014.01.056

来源: Elsevier

【 摘 要 】

Noble metal nanoparticle-based localized surface plasmon resonance (LSPR) is an advanced and powerful label-free biosensing technique which is well-known for its high sensitivity to the surrounding refractive index change in the local environment caused by the biomolecular interactions around the sensing area. The characteristics of the LSPR effect in such sensors are highly dependent on the size, shape and nature of the material properties of the metallic nanoparticles considered. Among the various types of metallic nanoparticles used in studies employing the LSPR technique, the use of gold nanorods (GNRs) has attracted particular attention for the development of sensitive LSPR biosensors, this arising from the unique and intriguing optical properties of the material. This paper provides a detailed review of the key underpinning science for such systems and of recent progress in the development of a number of LSPR-based biosensors which use GNR as the active element, including an overview of the sensing principle, the synthesis of GNRs, the fabrication of a number of biosensors, techniques for surface modification of GNRs and finally their performance in several biosensing applications. The review ends with a consideration of key advances in GNR-based LSPR sensing and prospects for future research and advances for the development of the GNR-based LSPR biosensors. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free