Highly sensitive and fast responsive ratiometric fluorescent probe for Cu2+ based on a naphthalimide-rhodamine dyad and its application in iving cell imaging

SENSORS AND ACTUATORS B-CHEMICAL

卷:236

Article

Tang, Jun¹  Ma, Saige¹  Zhang, Di²  Liu, Yaqi¹  Zhao, Yufen^1,3  Ye, Yong¹ 

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Phosphorus Chem Engn Res Ctr Henan Prov, Zhengzhou, Peoples R China

[2] Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou 450002, Peoples R China

[3] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

关键词: Fluorescence;    Ratiometric;    FRET;    Copper;    Cell imaging;    Naphthalimide-rhodaminea;   

DOI  :  10.1016/j.snb.2016.05.144

来源: Elsevier

【 摘 要 】

Based on fluorescent resonance energy transfer (FRET), we developed a ratiometric fluorescent probe 1 for sensing Cu2+. As expected, probe 1 exhibited high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Cu2+ in aqueous solution. A significant color change from pale yellow to pink could be observed, enabling naked-eye detection of Cu2+. Furthermore, fluorescence imaging experiment of Cu2+ in living MGC-803 cells demonstrated its value of practical applications in biological systems. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

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