An ocular iontophoretic device using PEDOT electrode for local drug delivery

SENSORS AND ACTUATORS B-CHEMICAL

卷:237

Article

Zhang, Yushi¹  Chen, Yao²  Qi, Yangjia¹  Huang, Dong¹  Yang, Mu¹  Yu, Xiaoxue¹  Hu, Yuntao³  Li, Zhihong¹ 

[1] Peking Univ, Inst Microelect, Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing, Peoples R China

[2] Peking Univ, Hosp 3, Dept Ophthalmol, Beijing, Peoples R China

[3] Beijing Tsinghua Changgung Hosp, Dept Ophthalmol, Beijing, Peoples R China

关键词: Ocular iontophoresis;    Drug delivery;    PEDOT electrode;   

DOI  :  10.1016/j.snb.2016.01.057

来源: Elsevier

【 摘 要 】

An ocular iontophoretic device using a biocompatible planar PEDOT electrode is reported. In vivo experiments on rabbit eyes demonstrated that the device can realize ocular iontophoresis effectively, simply, and conveniently. Compared with conventional eye cups, this device can be placed under the eyelid and deliver ions through a small area on the eyeball, reducing tissue damage during ion penetration. Devices were fabricated in different sizes for different cases. The efficiency was a function of the current, work time and solvent water content. The highest iontophoretic efficiency observed in the in vivo experiments was 396 ng/mL, while the efficiency observed in the controlled experiments was only 2.69 ng/mL. The temperature distribution was simulated and measured, and thermal injuries were not observed under an applied current of 1.5 mA. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free