Osmotic swelling pressure response of smart hydrogels suitable for chronically implantable glucose sensors

SENSORS AND ACTUATORS B-CHEMICAL

卷:144

Article

Lin, G.¹  Chang, S.²  Hao, H.³  Tathireddy, P.⁴  Orthner, M.⁴  Magda, J.^1,2  Solzbacher, F.^1,4,5 

[1] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Chem Engn, Salt Lake City, UT 84112 USA

[3] NW Univ Xian, Dept Chem Engn, Xian 710069, Peoples R China

[4] Univ Utah, Dept Elect & Comp Engn, Salt Lake City, UT 84112 USA

[5] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

关键词: Glucose sensor;    Hydrogel;    Piezoresistive sensor;    Smart material;   

DOI  :  10.1016/j.snb.2009.07.054

来源: Elsevier

【 摘 要 】

In the last few years, anew type of glucose-sensitive hydrogel (GSH) has been developed that shrinks with increasing glucose concentration due to the formation of reversible crosslinks. The first osmotic swelling pressure results measured for any member of this new class of GSH are reported, so that their suitability for use in sensors combining pressure transducers and smart gels can be evaluated. Comparison is also made with results obtained for an older type of GSH that expands with increasing glucose concentration due to an increase in the concentration of counterions within the gel. The newer type of GSH exhibits both faster kinetics and weaker fructose interference, and therefore is more suitable for in vivo glucose sensing. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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