Electrospun colourimetric sensors for detecting volatile amines

SENSORS AND ACTUATORS B-CHEMICAL

卷:322

Article

Ulrich, Sebastian¹  Moura, Sara Oliveira^1,2,3  Diaz, Yvonne⁴  Clerc, Michele¹  Guex, Anne Geraldine^1,5  de Alaniz, Javier Read⁴  Martins, Albino^2,3  Neves, Nuno M.^2,3  Rottmar, Markus⁵  Rossi, Rene M.¹  Fortunato, Giuseppino¹  Boesel, Luciano F.¹ 

[1] Empa, Swiss Fed Labs Mat Sci & Technol, Lab Biomimet Membranes & Text, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland

[2] Univ Minho, I3Bs Res Inst Biomat Biodegradables & Biomimet, European Inst Excellence Tissue Engn & Regenerat, 3Bs Res Grp, AvePk Parque Ciencia & Tecnol, P-4805017 Barco, Guimaraes, Portugal

[3] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal

[4] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[5] Empa, Swiss Fed Labs Mat Sci & Technol, Biointerfaces, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland

关键词: Volatile amines;    Donor-acceptor Stenhouse adducts (DASAs);    Electrospinning;    Colourimetric detection;    Biomedical sensors;   

DOI  :  10.1016/j.snb.2020.128570

来源: Elsevier

【 摘 要 】

Volatile amines are present in our daily life as a result of chemical manufacturing, agriculture and farming, release by rotten food or exhalation under certain medical conditions or diseases. An efficient, fast and low-cost method for detecting these compounds is desired due to their often-toxic nature. The development of a highly sensitive electrospun colourimetric sensor for the detection of volatile amines is reported here. Composite microfibrous meshes were obtained by incorporating activated furan adducts (FAs) into electrospun polymer meshes. Volatile amines penetrate into the amorphous polymer matrix where the ring-opening reaction with FAs yields strongly coloured donor-acceptor Stenhouse adducts (DASAs), resulting in an easily observable visible mesh colour change. Different FAs were evaluated, including a highly reactive FA yielding 3rd generation DASAs. The colourimetric responses were assessed qualitatively and quantitatively by RGB (red, green and blue) colour analysis. The sensors showed a detection range with high sensitivity down to the low-ppb range. Additionally, the covalent attachment of FAs to a polymer backbone anchored them inside the fibres and successfully prevented leaching. Thus, the cytotoxic effect of leached FAs was eliminated, as shown by indirect and direct contact tests with human fibroblasts.

【 授权许可】

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