A nano-carbon electrode optimized for adsorptive stripping voltammetry: Application to detection of the stimulant selegiline in authentic saliva

SENSORS AND ACTUATORS B-CHEMICAL

卷:279

Article

dos Santos, Wallans T. P.^1,2  Amin, Hatem M. A.²  Compton, Richard G.² 

[1] Univ Fed Vales Jequitinhonha & Mucuri, Dept Pharm, Campus JK, BR-39100000 Diamantina, MG, Brazil

[2] Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, South Parks Rd, Oxford OX1 3QZ, England

关键词: Adsorptive stripping voltammetry;    Carbon Black;    Doping control;    Saliva;    Selegiline;   

DOI  :  10.1016/j.snb.2018.10.037

来源: Elsevier

【 摘 要 】

A multilayer Carbon Black (CB) modified Glassy Carbon Electrode (GCE) is proposed, developed and optimized for Adsorptive Stripping Voltammetry (AdSV). The thick (up to 1000 monolayers) multilayer CB modification offers a significant enhancement in sensitivity for AdSV but not diffusive voltammetry. The detection of the stimulant selegiline, which is a prohibited drug for athletes in sports competitions, is used as model for application of the proposed electrochemical method in saliva samples. The analytical performance of the CB-GCE for detection of seligeline in authentic saliva samples revealed a limit of detection of 0.12 mu mol L-1 which is sufficiently low to allow a possible application of this fast method in the doping control of this drug.

【 授权许可】

Free