Nano-fiber scaffold electrodes based on PEDOT for cell stimulation

SENSORS AND ACTUATORS B-CHEMICAL

卷:142

Article

Bolin, Maria H.¹  Svennersten, Karl²  Wang, Xiangjun^1,4  Chronakis, Ioannis S.³  Richter-Dahlfors, Agneta²  Jager, Edwin W. H.¹  Berggren, Magnus¹ 

[1] Linkoping Univ, Dept Sci & Technol, SE-60174 Norrkoping, Sweden

[2] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

[3] Ind Res & Dev Corp, Swedish Inst, Swerea IVF, SE-43122 Molndal, Sweden

[4] Univ London Imperial Coll Sci Technol & Med, Dept Phys, Expt Solid State Grp, London SW7 2AZ, England

关键词: Poly(ethylenedioxythiophene) (PEDOT);    Electrospinning;    Poly(ethylene terephthalate) (PET);    Cell stimulation;    SH-SY5Y neuroblastoma cells;    Nano-fibers;   

DOI  :  10.1016/j.snb.2009.04.062

来源: Elsevier

【 摘 要 】

Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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