Towards an automated MEMS-based characterization of benign and cancerous breast tissue using bioimpedance measurements

SENSORS AND ACTUATORS B-CHEMICAL

卷:199

Article

Pandya, Hardik J.¹  Kim, Hyun Tae¹  Roy, Rajarshi¹  Chen, Wenjin²  Cong, Lei²  Zhong, Hua³  Foran, David J.²  Desai, Jaydey P.¹ 

[1] Univ Maryland, Syst Res Inst, Maryland Robot Ctr, Dept Mech Engn, College Pk, MD 20742 USA

[2] Rutgers State Univ, Rutgers Canc Inst New Jersey, Ctr Biomed Imaging & Informat, New Brunswick, NJ 08901 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol & Lab Med, New Brunswick, NJ 08903 USA

关键词: MEMS sensor;    Inter-digitated electrodes;    Bioimpedance;    Breast cancer;    Tissue microarray;   

DOI  :  10.1016/j.snb.2014.03.065

来源: Elsevier

【 摘 要 】

Micro-electro-mechanical-systems (MEMS) are desirable for use within medical diagnostics because of their capacity to manipulate and analyze biological materials at the microscale. Biosensors can be incorporated into portable lab-on-a-chip devices to quickly and reliably perform diagnostics procedure on laboratory and clinical samples. In this paper, electrical impedance-based measurements were used to distinguish between benign and cancerous breast tissues using microchips in a real-time and label-free manner. Two different microchips having inter-digitated electrodes (10 mu m width with 10 mu m spacing and 10 mu m width with 30 mu m spacing) were used for measuring the impedance of breast tissues. The system employs Agilent E4980A precision impedance analyzer. The impedance magnitude and phase were collected over a frequency range of 100 Hz to 2 MHz. The benign group and cancer group showed clearly distinguishable impedance properties. At 200 kHz, the difference in impedance of benign and cancerous breast tissue was significantly higher (3110 Omega) in the case of microchips having 10 mu m spacing compared to microchip having 30 mu m spacing (568 Omega). (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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